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Esthesioneuroblastoma (es-THEE-zee-o-NOO-row-blas-TOE-muh) is a rare type of cancer that begins in the part of the brain that interprets smell (olfactory bulb). Esthesioneuroblastoma is also called olfactory neuroblastoma. Esthesioneuroblastoma, which can occur at any age, often causes a tumor to form behind the nose that may affect the sinuses. People with esthesioneuroblastoma may lose the sense of smell, have frequent nosebleeds and experience difficulty breathing through their nostrils. Esthesioneuroblastoma treatments include surgery, radiation and chemotherapy.