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Rebound headaches (medication- overuse headaches) are caused by regular, long-term use of medication to treat headaches, such as migraine. Pain relievers offer relief for occasional headaches. But if you take them more than a couple of days a week, they may trigger rebound headaches.It appears that any medication taken for pain relief can cause rebound headaches, but only if you already have a headache disorder. Pain relievers taken regularly for another condition, such as arthritis, have not been shown to cause rebound headaches in people who never had a headache disorder.Rebound headaches usually stop when you stop taking the pain medication. It`s tough in the short term, but your doctor can help you beat rebound headaches for long-term relief.

Signs and symptoms of rebound headaches may differ according to the type of original headache being treated and the medication used. Rebound headaches tend to:

  • Occur every day or nearly every day, often waking you in the early morning.
  • Improve with pain relief medication but then return as your medication wears off.

Other signs and symptoms may include:

Nausea, Listlessness, Restlessness, difficulty concentrating, memory problems, Irritability etc.

Seek immediate medical care if your headache:

  • Is sudden and severe.
  • Accompanies a fever, stiff neck, rash, confusion, seizure, double vision, weakness, numbness or difficulty speaking.
  • Follows a head injury. 
  • Gets worse despite rest and pain medication.
  • Is a new type for someone older than 50.
  • Wakes you from sleep.

Rebound headaches can develop if you frequently use headache medication. Although the risk of developing medication-overuse headache varies depending on the medication, any acute headache medication has the potential to lead to rebound headaches, including:

  • Simple pain relievers. Common pain relievers such as aspirin and acetaminophen (Tylenol, others) may contribute to rebound headaches — especially if you exceed the recommended daily dosages. Pain relievers such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) have a low risk of contributing to medication-overuse headaches.
  • Combination pain relievers. Over-the-counter (OTC) pain relievers that combine caffeine, aspirin and acetaminophen (Excedrin, others) are common culprits. This group also includes prescription medications such as Fiorinal, which contains the sedative butalbital. Butalbital-containing compounds have an especially high risk of causing rebound headaches, so it`s best not to take them to treat headaches. If you do take this type of drug, limit its use to no more than four days a month.
  • Migraine medications. Various migraine medications have been linked with rebound headaches, including triptans (Imitrex, Zomig, others) and certain ergots — such as ergotamine (Ergomar, others). These medications have a moderate risk of causing medication-overuse headaches. The ergot dihydroergotamine (D.H.E. 45) appears to have a lower potential for leading to this problem.
  • Opiates. Painkillers derived from opium or from synthetic opium compounds include combinations of codeine and acetaminophen (Tylenol with Codeine No. 3 and No. 4, others). These medications have a high risk of causing rebound headaches.
  • Daily doses of caffeine— from your morning coffee, your afternoon soda, and pain relievers and other products containing this mild stimulant — may fuel rebound headaches, as well. Read product labels to make sure you`re not wiring your system with more caffeine than you realize.

Risk factors for developing rebound headaches include:

  • History of chronic headaches. A history of migraines, tension-type headaches or other chronic headaches puts you at risk.
  • Frequent use of headache medications. Your risk increases if you use combination analgesics, ergotamine or triptans 10 or more days a month or simple analgesics more than 15 days a month — especially if this regular use continues for three or more months.